I would call the pronoun iste a "second person demonstrative pronoun"1, meaning roughly "that thing near you". It can also have a pejorative tone, implying that the speaker does not approve of the thing. I am not confident in my ability to render idiomatic examples in English; let me know if I need to elaborate on this tone.
Can the adverbs istuc, istic, and istinc derived from iste also have such a tone, or do they only mean "to/in/from where you are" without any judgement of the place?
1 I mean this in the same sense as hic is a "first person demonstrative pronoun"; hic refers to something close to or possessed by the speaker but not to the speaker. Similarly, iste does not refer to the addressee, but something close to them. This meaning is not always strong, but quite often it is.