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A tad nuance is fine, as long as the original meaning is there.

Would appreciate it if someone took time to do this. Don't be obliged though..

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I would suggest:

Maxime nos docent eae quaestiones, ad quas respondere non possumus.

Or, less literally:

Ex eis quaestionibus maxime discimus, ad quas quod respondeamus non habemus.

Because I google'd a little and noticed that quod respondeamus is a really popular phrase, occurring in lots of variations, e.g. ad hanc quaestionem adhuc nihil certi est, quod respondeamus or vix habebimus quod respondeamus or quod respondeamus, facile est in promtu etc.

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  • I like these suggestions. One question though: Is quaestio a good choice here? It sounds more like "search" or "investigation" than "question" to me, but those ideas can work well in this context. Depends on what the OP is after.
    – Joonas Ilmavirta
    Commented Nov 13, 2021 at 21:16
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    @JoonasIlmavirta res ita mihi esse videtur: Si te rogaverim, quo modo stellae formentur, ad hoc rogatum meum tibi licuerit repondere; sin apud conventum astronomorum de stellarum formatione quaesitum sit, ad illam quaestionem astronomis licuerit respondere. Commented Nov 13, 2021 at 22:13
  • Assentior! Fortasse vero quaestiones plus quam rogata ad vitam humanam eiusque problemata gravia attinent. De his credo rogatorem nobis scribentem cogitasse.
    – Joonas Ilmavirta
    Commented Nov 13, 2021 at 22:21
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If you're OK with a somewhat gnomic translation which isn't very literal but may nevertheless get at the intended sense, you could go with something like

Plurima ex ignotis noscimus.

This is literally "It's from unknown things that we come to know / learn the most". It leaves out the "questions" and might require some more explanation than a more faithful translation would, but maybe it's useful for your purposes.

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